The steric effect of a trifluoromethyl group

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Abstract

In the study of ene reaction of trifluoromethyl ketones, a trifluoromethyl group was found to behave as a much larger substituent than commonly believed. Similar results were obtained in the dehydration of trif1uoromethyl homoallyl alcohols. © 1991, The Pharmaceutical Society of Japan. All rights reserved.

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Nagai, T., Nishioka, G., Koyama, M., Ando, A., Miki, T., & Kumadaki, I. (1991). The steric effect of a trifluoromethyl group. Chemical and Pharmaceutical Bulletin, 39(1), 233–235. https://doi.org/10.1248/cpb.39.233

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