Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury

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Abstract

Renal ischemia-reperfusion (I/R) is an important etiopathological mechanism of acute renal failure (ARF). Despite improvements in the treatment of ARF, it is associated with significant morbidity and mortality. I/R injury also occurs during renal transplantation and leads to reduced allograft survival. Sex differences have been found in I/R injury in many different organs including the kidney. Women have half the mortality of men in ARF. In animal models also, females are protected against renal I/R injury. The mechanisms by which sex affects the outcome to renal I/R injury are being actively investigated. This review will examine the evidence for gender differences in renal I/R injury and discuss the probable mechanisms by which sex affects the renal response to I/R injury. © 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

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Kher, A., Meldrum, K. K., Wang, M., Tsai, B. M., Pitcher, J. M., & Meldrum, D. R. (2005, September 1). Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury. Cardiovascular Research. https://doi.org/10.1016/j.cardiores.2005.05.005

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