To examine the similarity of wide-field fundus autofluorescence (FAF) imaging in inherited retinal dystrophy between siblings and between parents and their children. The subjects included 17 siblings (12 with retinitis pigmentosa and 5 with cone rod dystrophy) and 10 parent-child pairs (8 with retinitis pigmentosa and 2 with cone rod dystrophy). We quantified the similarity of wide-field FAF using image processing techniques of cropping, binarization, superimposition, and subtraction. The estimated similarity of the siblings was compared with that of the parent-child pairs and that of the age-matched unrelated patients. The similarity between siblings was significantly higher that of parent-child pairs or that of agematched unrelated patients ( P = 0.004 and P = 0.049, respectively). Wide-field FAF images were similar between siblings with inherited retinal dystrophy but different between parent-child pairs. This suggests that aging is a confounding factor in genotype- phenotype correlation studies.
CITATION STYLE
Furutani, Y., Ogino, K., Oishi, A., Gotoh, N., Makiyama, Y., Oishi, M., … Yoshimura, N. (2016). Intra-familial similarity of wide-field fundus autofluorescence in inherited retinal dystrophy. In Advances in Experimental Medicine and Biology (Vol. 854, pp. 299–305). Springer New York LLC. https://doi.org/10.1007/978-3-319-17121-0_40
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