Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS

Christopher J. Burns; Michael F. Harte; Xianyong Bu; Emmanuelle Fantino; Marilena Giarrusso; Max Joffe; Margarita Kurek; Fiona S. Legge; Pasquale Razzino; Stephen Su; Herbert Treutlein; Soo San Wan; Jun Zeng; Andrew F. Wilks

Journal Article

Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS

Burns C
Harte M
Bu X
et al.

Bioorganic and Medicinal Chemistry Letters (2009) 19(4) 1206-1209

DOI: 10.1016/j.bmcl.2008.12.073

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Abstract

A series of 2-(α-methylbenzylamino) pyrazines have shown to be potent inhibitors of the FMS tyrosine receptor kinase. Details of SAR studies, modeling and synthesis of compounds within this series are reported. © 2009 Elsevier Ltd. All rights reserved.

Author supplied keywords

CSF-1
CSF-1R
FMS
Kinase inhibitor
M-CSF-1
Macrophage

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APA

Burns, C. J., Harte, M. F., Bu, X., Fantino, E., Giarrusso, M., Joffe, M., … Wilks, A. F. (2009). Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS. Bioorganic and Medicinal Chemistry Letters, 19(4), 1206–1209. https://doi.org/10.1016/j.bmcl.2008.12.073

Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS

Abstract

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