Cardiovascular effects of ketamine given to relieve penile turgescence after high doses of fentanyl

Abstract

Prior administration of pancuronium and high-dose fentanyl completely blocked the stimulating effect of ketamine on the cardiovascular system. Ketamine 0.5-1.8 mgxkg-1 given intravenously produced detumescence in all four patients without electrocardiographic evidence of ischemia or dysrhythmia and without changes in hemodynamic variables.