Islet grafts have demonstrated that patients with diabetes would benefit greatly by β-cell therapy. However, the paucity of available islets for transplantation as well as the immunological barriers faced in allogeneic transplantation represent a tremendous barrier to regenerative approaches to the treatment of diabetes. Here, we present a strategy and protocols to transdifferentiate developmentally related hepatocytes into β-cells by the ectopic expression of critical β-cell transcription factors. © 2009 Humana Press.
CITATION STYLE
Thowfeequ, S., Li, W. C., Slack, J. M. W., & Tosh, D. (2009). Reprogramming of liver to pancreas. Methods in Molecular Biology, 482, 407–418. https://doi.org/10.1007/978-1-59745-060-7_25
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