Synthesis of 8-(5-Aryl-4-Octyl-2-Phenyl-3, 4-Dihydro-2H-Pyrazol- 3-yl)-Octanoic acid ethyl esters via 1, 3-Dipolar Cycloaddition Reaction

Abstract

Aldehyde phenyl hydrazones 2a-i undergo oxidative dehydrogenation with Chloramine-T to give nitrile imines, which are trapped in situ by ethyl oleate 1 to afford 8-(5-Aryl-4-octyl-2-phenyl-3,4-dihydro-2H-pyrazol-3-yl)-octanoic acid ethyl esters 3a-i in good yield. The structures of the cycloadducts were confirmed by spectral studies and elemental analysis.