Lineage-tracing methods and the kidney

35Citations
Citations of this article
94Readers
Mendeley users who have this article in their library.
Get full text

Abstract

The kidney is a complex organ with over 30 different cell types, and understanding the lineage relationships between these cells is challenging. During nephrogenesis, a central question is how the coordinated morphogenesis, growth, and differentiation of distinct cell types leads to development of a functional organ. In mature kidney, understanding cell division and fate during injury, regeneration and aging are critical topics for understanding disease. Genetic lineage tracing offers a powerful tool to decipher cellular hierarchies in both development and disease because it allows the progeny of a single cell, or group of cells, to be tracked unambiguously. Recent advances in this field include the use of inducible recombinases, multicolor reporters, and mosaic analysis. In this review, we discuss lineage-tracing methods focusing on the mouse model system and consider the impact of these methods on our understanding of kidney biology and prospects for future application. © 2013 International Society of Nephrology.

Figures

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Humphreys, B. D., & Dirocco, D. P. (2014). Lineage-tracing methods and the kidney. Kidney International. Nature Publishing Group. https://doi.org/10.1038/ki.2013.368

Readers over time

‘13‘14‘15‘16‘17‘18‘19‘20‘21‘22‘23‘2405101520

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 38

55%

Researcher 24

35%

Professor / Associate Prof. 6

9%

Lecturer / Post doc 1

1%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 24

30%

Medicine and Dentistry 23

29%

Agricultural and Biological Sciences 20

25%

Nursing and Health Professions 13

16%

Save time finding and organizing research with Mendeley

Sign up for free
0