Structural analysis of the jacalin-related lectin MornigaM from the black mulberry (Morus nigra) in complex with mannose

Abstract

The structures of MornigaM and the MornigaM-mannose complex have been determined at 1.8 Å and 2.0 Å resolution, respectively. Both structures adopt the typical β-prism motif found in other jacalin-related lectins and their tetrameric assembly closely resembles that of jacalin. The carbohydrate-binding cavity of MornigaM readily binds mannose. No major structural rearrangements can be observed in MornigaM upon binding of mannose. These results allow corroboration of the structure-function relationships within the small group of Moraceae lectins. © 2005 FEBS.