Exploring semantic verbal fluency patterns and their relationship to age and Alzheimer's disease in adults with Down syndrome

N/ACitations
Citations of this article
33Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Introduction: Adults with Down syndrome (DS) are at ultra-high risk of developing Alzheimer's disease (AD), characterized by poor episodic memory and semantic fluency in the preclinical phase in the general population. We explored semantic fluency performance in DS and its relationship to age, AD, and blood biomarkers. Methods: A total of 302 adults with DS at baseline and 87 at follow-up from the London Down Syndrome Consortium cohort completed neuropsychological assessments. Blood biomarkers were measured with the single molecule array technique in a subset of 94 participants. Results: Poorer verbal fluency performance was observed as age increases. Number of correct words declined in those with AD compared to those without over 2 years and was negatively correlated with neurofilament light (r = –0.37, P =.001) and glial fibrillary acidic protein (r = –0.31, P =.012). Discussion: Semantic fluency may be useful as an early indicator of cognitive decline and provide additional information on AD-related change, showing associations with biomarkers in DS.

Cite

CITATION STYLE

APA

Mgaieth, F., Baksh, R. A., Startin, C. M., Hamburg, S., Hithersay, R., Pape, S., … Strydom, A. (2023). Exploring semantic verbal fluency patterns and their relationship to age and Alzheimer’s disease in adults with Down syndrome. Alzheimer’s and Dementia, 19(11), 5129–5137. https://doi.org/10.1002/alz.13097

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free