Physiological rationale for renal denervation therapy in hypertension

Abstract

Systemic hypertension is of major importance world-wide due to its significant public health implications. Hypertension is a common clinical disorder encountered not just in the western or industrialized world but also in underdeveloped and emerging countries. In most populations (at least in the western hemisphere) one in three individuals have hypertension and hence it is the largest contributor to excessive mortality and morbidity. Hypertension is a merciless killer without sparing the attributes of age, gender, and socio-economic status. Despite remarkable advances in the physiology, and pharmacology of hypertension, blood pressure (BP) control rates are quite low globally. Whatever the reasons may be, most patients with hypertension fail to achieve recommended goal BP levels.