Skin Sodium and Hypertension: a Paradigm Shift?

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Abstract

Purpose of Review: Dietary sodium is an important trigger for hypertension and humans show a heterogeneous blood pressure response to salt intake. The precise mechanisms for this have not been fully explained although renal sodium handling has traditionally been considered to play a central role. Recent Findings: Animal studies have shown that dietary salt loading results in non-osmotic sodium accumulation via glycosaminoglycans and lymphangiogenesis in skin mediated by vascular endothelial growth factor-C, both processes attenuating the rise in BP. Studies in humans have shown that skin could be a buffer for sodium and that skin sodium could be a marker of hypertension and salt sensitivity. Summary: Skin sodium storage could represent an additional system influencing the response to salt load and blood pressure in humans.

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Selvarajah, V., Connolly, K., McEniery, C., & Wilkinson, I. (2018, November 1). Skin Sodium and Hypertension: a Paradigm Shift? Current Hypertension Reports. Current Medicine Group LLC 1. https://doi.org/10.1007/s11906-018-0892-9

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