Sexual dimorphism in gastric cancer: tumor-associated neutrophils predict patient outcome only for women

21Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Purpose: Tumor-associated neutrophils (TANs) are part of the tumor immune microenvironment (TIME) and may contribute to gastric cancer (GC) biology. We hypothesized that TAN are enriched in the TIME, show sex-specific differences, and correlate with patient outcome. Methods: We analyzed the distribution and putative tumor biological significance of TANs in a well-characterized, therapy-naïve, European GC cohort using immunohistochemical staining of myeloperoxidase (MPO), and digital image analysis using Definiens Tissue Studio®. Results: Different tumor compartments were examined, and TAN densities were correlated with various clinicopathological patient characteristics. TAN density showed a large interindividual variability ranging from 0 to 6711.0 TANs/mm2. Intratumoral distribution patterns were inhomogeneous (tumor surface vs. tumor center vs. invasion front) and correlated significantly with Laurén phenotype, tumor grade, and microsatellite status in the tumor center and invasion front. In the multivariate analysis, TAN density in the invasion front was an independent predictor of tumor-specific survival only for women (HR = 2.77, p < 0.001). In men, no correlation was found between TAN density and survival. Conclusion: With regard to TANs, our study independently validates sexual dimorphism in GC biology.

Cite

CITATION STYLE

APA

Clausen, F., Behrens, H. M., Krüger, S., & Röcken, C. (2020). Sexual dimorphism in gastric cancer: tumor-associated neutrophils predict patient outcome only for women. Journal of Cancer Research and Clinical Oncology, 146(1), 53–66. https://doi.org/10.1007/s00432-019-03082-z

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free