Prevalence of Myopic Macular Features in Dutch Individuals of European Ancestry with High Myopia

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Importance: High myopia incidence and prevalence is increasing worldwide, and the visual burden caused by myopia is expected to rise accordingly. Studies investigating the occurrence of myopic complications in individuals of European ancestry with high myopia are scarce, hampering insights into the frequency of myopic retinal complications in European individuals and their visual burden. Objective: To assess the frequency of myopic macular features in individuals of European ancestry with high myopia. Design, Setting, and Participants: This cross-sectional analysis of the Dutch Myopia Study (MYST) and individuals with high myopia from the Rotterdam Study (RS) included 626 patients with high myopia (spherical equivalent of refractive error [SER] ≤-6 diopters [D] or axial length [AL] ≥26 mm) who underwent an extensive ophthalmic examination including multimodal retinal imaging. In addition to this combination of a population-based cohort study and mix-based high myopia study, a systematic literature review was also performed to compare findings with studies of individuals of Asian ancestry. Exposures: High myopia, age, and AL. Main Outcomes and Measures: Frequency of myopic macular and optic disc features: tessellated fundus, myopic macular degeneration (MMD), staphyloma, peripapillary intrachoroidal cavitation, peripapillary atrophy (PPA), and "plus" lesions (choroidal neovascularization, Fuchs spot, and lacquer cracks). Results: The mean (SD) SER of the combined study population (MYST and RS) was -9.9 (3.2) D; the mean (SD) age was 51.4 (15.1) years, and 387 (61.8%) were women. The prevalence of MMD was 25.9% and increased with older age (P for trend




Haarman, A. E. G., Tedja, M. S., Brussee, C., Enthoven, C. A., Van Rijn, G. A., Vingerling, J. R., … Klaver, C. C. W. (2022). Prevalence of Myopic Macular Features in Dutch Individuals of European Ancestry with High Myopia. JAMA Ophthalmology, 140(2), 115–123.

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