A modified regimen of extracorporeal cardiac shock wave therapy for treatment of coronary artery disease

Abstract

Background: Cardiac shock wave therapy (CSWT) improves cardiac function in patients with severe coronary artery disease (CAD). We aimed to evaluate the clinical outcomes of a new CSWT treatment regimen. Methods. The 55 patients with severe CAD were randomly divided into 3 treatment groups. The control group (n = 14) received only medical therapy. In group A (n = 20), CSWT was performed 3 times within 3 months. In group B (n = 21), patients underwent 3 CSWT sessions/week, and 9 treatment sessions were completed within 1 month. Primary outcome measurement was 6-minute walk test (6MWT). Other measurements were also evaluated. Results: The 6MWT, CCS grading of angina, dosage of nitroglycerin, NYHA classification, and SAQ scores were improved in group A and B compared to control group. Conclusions: A CSWT protocol with 1 month treatment duration showed similar therapeutic efficacy compared to a protocol of 3 months duration. Clinical trial registry. We have registered on ClinicalTrials.gov, the protocol ID is CSWT IN CHINA. © 2012 Wang et al.; licensee BioMed Central Ltd.