Characteristics of Helicobacter pylori natural transformation

Citations of this article
Mendeley users who have this article in their library.


For Helicobacter pylori, which exhibits substantial genetic diversity, many strains are naturally competent for transformation by exogenous DNA. To better understand the mechanism of natural transformation and its role in the generation of diversity, we sought to systematically identify factors important for natural transformation in H. pylori. We now show that the highest frequency of H. pylori transformation occurs when DNA is introduced prior to exponential phase growth, and that it is a saturable phenomenon. That transformation can be inhibited by DNA from Helicobacter (H. pylori and Helicobacter bilis) but not Escherichia coli suggests specificity based on DNA source. Finally, the cag island was determined to be unnecessary for high-frequency transformation. Copyright (C) 2000 Federation of European Microbiological Societies.




Israel, D. A., Lou, A. S., & Blaser, M. J. (2000). Characteristics of Helicobacter pylori natural transformation. FEMS Microbiology Letters, 186(2), 275–280.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free