Characterizing exons and introns by regularity of nucleotide strings

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Translation of nucleotides into a numeric form has been approached in many ways and has allowed researchers to investigate the properties of protein-coding sequences and noncoding sequences. Typically, more pronounced long-range correlations and increased regularity were found in intron-containing genes and in non-transcribed regulatory DNA sequences, compared to cDNA sequences or intron-less genes. The regularity is assessed by spectral tools defined on numerical translates. In most popular approaches of numerical translation the resulting spectra depend on the assignment of numerical values to nucleotides. Our contribution is to propose and illustrate a spectra which remains invariant to the translation rules used in traditional approaches.




Woods, T., Preeprem, T., Lee, K., Chang, W., & Vidakovic, B. (2016). Characterizing exons and introns by regularity of nucleotide strings. Biology Direct, 11(1), 6.

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