Who choosing what? The evolution of the use of 'choice' in the NHS, and its importance for New Labour

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Abstract

Substantial evidence links Myc-PI3K/AKT signalling to the most aggressive subtype of medulloblastoma (MB) and this axis in MB therapy. In this study, we advance understanding of how Myc-PI3K/AKT signalling contributes to this malignancy, specifically, in identifying the Myc-interacting protein JPO2 and its partner binding protein LEDGF/p75 as critical modulators of PI3K/AKT signalling and metastasis in MB. JPO2 overexpression induced metastatic MB in vivo through two synergistic feed-forward regulatory circuits involving LEDGF/p75 and AKT that promote metastatic phenotypes in this settng. Overall, our findings highlight two novel pro-metastatic loci in MB and point to the JPO2:LEDGF/p75 protein complex as a potentially new targetable component of P13K/AKT signalling in MB.

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Greener, I. (2003). Who choosing what? The evolution of the use of “choice” in the NHS, and its importance for New Labour. In C. Bochel, N. Ellison, & M. Powell (Eds.), Social Policy Review: UK and international perspectives, Volume 15 (pp. 49–70). Bristol: The Policy Press. https://doi.org/10.1158/0008-5472.CAN-15-2194

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