A close family resemblance: The importance of structure in understanding cytochromes P450

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Abstract

Cytochromes P450 comprise a very large superfamily of hemeproteins which generally monooxygenate hydrophobic compounds. P450s appear to have a common conserved structural core, yet are variable in regions involved in substrate recognition and binding, and in redox-partner binding. These differences can be identified by an analysis in which structural alignments and homology models are used to compare the various classes and families of P450s.

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Peterson, J. A., & Graham, S. E. (1998). A close family resemblance: The importance of structure in understanding cytochromes P450. Structure, 6(9), 1079–1085. https://doi.org/10.1016/S0969-2126(98)00109-9

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