The closely related CD103+ dendritic cells (DCs) and lymphoid-resident CD8+ DCs differ in their inflammatory functions

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Abstract

Migratory CD103 + and lymphoid-resident CD8 + dendritic cells (DCs) share many attributes, such as dependence on the same transcription factors, cross-presenting ability and expression of certain surface molecules, such that it has been proposed they belong to a common sub-lineage. The functional diversity of the two DC types is nevertheless incompletely understood. Here we reveal that upon skin infection with herpes simplex virus, migratory CD103 + DCs from draining lymph nodes were more potent at inducing Th17 cytokine production by CD4 + T cells than CD8 + DCs. This superior capacity to drive Th17 responses was also evident in CD103 + DCs from uninfected mice. Their differential potency to induce Th17 differentiation was reflected by higher production of IL-1β and IL-6 by CD103 + DCs compared with CD8 + DCs upon stimulation. The two types of DCs from isolated lymph nodes also differ in expression of certain pattern recognition receptors. Furthermore, elevated levels of GM-CSF, typical of those found in inflammation, substantially increased the pool size of CD103 + DCs in lymph nodes and skin. We argue that varied levels of GM-CSF may explain the contrasting reports regarding the positive role of GM-CSF in regulating development of CD103 + DCs. Together, we find that these two developmentally closely-related DC subsets display functional differences and that GM-CSF has differential effect on the two types of DCs. © 2014 Jiao et al.

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APA

Jiao, Z., Bedoui, S., Brady, J. L., Walter, A., Chopin, M., Carrington, E. M., … Zhan, Y. (2014). The closely related CD103+ dendritic cells (DCs) and lymphoid-resident CD8+ DCs differ in their inflammatory functions. PLoS ONE, 9(3). https://doi.org/10.1371/journal.pone.0091126

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