A comparison of the desensitising efficacy of two commercially available dentifrices with different modes of action was conducted in a randomised, examiner-blind, two-arm, parallel group, 8-week, longitudinal clinical study. Dentifrice A, (Sensodyne Multi Action Iso-Active), contained 50000 ppm KNO 3 and 1450 ppm fluoride as NaF. Dentifrice B, Colgate Sensitive Pro-Relief, contained a combination of 80000 ppm arginine, bicarbonate, calcium carbonate, and 1450 ppm fluorine as NaMFP. Subjects ( N=110 ), stratified into two groups ( N=55 ), brushed twice-daily for 60 s, over an 8-week period. Sensitivity status, compliance, and safety were determined at 1, 2, 4, and 8 weeks. A fixed-effects ANCOVA statistical model was applied to the Intent-To-Treat population using a two-sided 5% significance level. After 8 weeks, the treatment groups using Dentifrice A and Dentifrice B exhibited mean reductions from baseline of 49% and 45% in air sensitivity visual analogue scale (VAS) score, 61% (both) in examiner-based Schiff Sensitivity score, and clinically significant reductions in tactile pain threshold; all reductions were statistically significant ( P<0.0001 ). Both treatment groups also exhibited significant reductions across all sensitivity measures at 1, 2, and 4 weeks ( P≤0.0059 , Dentifrice A; P≤0.0137 , Dentifrice B).
Barlow, A. P., He, J., Tian, C., Jeffery, P., Mason, S. C., Tai, B. J., … Du, M. Q. (2012). A comparative evaluation of the efficacy of two novel desensitising dentifrices. International Journal of Dentistry. https://doi.org/10.1155/2012/896143