Conjugal transfer of aminoglycoside and macrolide resistance between Enterococcus faecium isolates in the intestine of streptomycin-treated mice

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Abstract

The purpose was to study conjugal transfer of resistance genes between a multi-resistant Enterococcus faecium isolate and a sensitive E. faecium isolate. Co-transfer of erm(B)-Tn5405-like element and aac(6′)-Ie- aph(2″)-Ia was obtained in both in vivo and in vitro. Plasmid profiles and Southern blots showed that both the erm(B)-Tn5405-like element and aac(6′)-Ie-aph(2″)-Ia were placed on the same large plasmid (>147 kb). These data show to our knowledge the first co-transfer of the erm(B)-Tn5405-like element and aac(6′)-Ie- aph(2″)-Ia. The in vivo study also indicates that transfer of resistance genes between enterococci might occur under natural conditions in the gut of animals. © 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

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Lester, C. H., Frimodt-Moller, N., & Hammerum, A. M. (2004). Conjugal transfer of aminoglycoside and macrolide resistance between Enterococcus faecium isolates in the intestine of streptomycin-treated mice. FEMS Microbiology Letters, 235(2), 385–391. https://doi.org/10.1016/j.femsle.2004.04.050

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