Context dependent substitution biases vary within the human genome

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Abstract

Models of sequence evolution typically assume that different nucleotide positions evolve independently. This assumption is widely appreciated to be an over-simplification. The best known violations involve biases due to adjacent nucleotides. There have also been suggestions that biases exist at larger scales, however this possibility has not been systematically explored.

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Nevarez, P. A., DeBoever, C. M., Freeland, B. J., Quitt, M. A., & Bush, E. C. (2010). Context dependent substitution biases vary within the human genome. BMC Bioinformatics, 11. https://doi.org/10.1186/1471-2105-11-462

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