The correlation of age with chemotherapy-induced ovarian function failure in breast cancer patients

  • Vriens I
  • De Bie A
  • Aarts M
  • et al.
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Abstract

Purpose: To assess the incidence of chemotherapy-induced ovarian function failure (COFF) based on estradiol and follicle stimulating hormone (FSH) monitoring in premenopausal women with hormone-receptor positive breast cancer treated with second and third generation (neo-)adjuvant chemotherapy. Results: We identified 115 eligible women. Two years after start of chemotherapy, COFF was significantly more often present in women = 40 years (85.6%) as compared to women < 40 years (8.7%). Only age was significantly associated with COFF two years after start of chemotherapy (HR 12.26; 95% CI 5.21-28.86). In 50% of the patients, premenopausal hormone levels were the first or only evidence of ovarian function recovery (OFR). Materials and Methods: We included all premenopausal women with hormonereceptor positive breast cancer treated with anthracycline-based chemotherapy, with or without taxanes, in our university hospital in the Netherlands in the years 2005-2013. Patients were 3-monthly monitored for ovarian function. Cox proportional hazards model was used to determine the predictive impact of various parameters on t he occurrence of COFF. Conclusions: After second- or third generation (neo-)adjuvant chemotherapy, COFF was still present in 8.7% of patients < 40 years after two years. FSH and estradiol monitoring may be relevant for those in whom ovarian function suppression is considered an additional effective endocrine treatment.

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APA

Vriens, I. J. H., De Bie, A. J. R., Aarts, M. J. B., de Boer, M., van Hellemond, I. E. G., Roijen, J. H. E., … Tjan-Heijnen, V. C. G. (2017). The correlation of age with chemotherapy-induced ovarian function failure in breast cancer patients. Oncotarget, 8(7). https://doi.org/10.18632/oncotarget.14532

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