A critical role for Stat3 signaling in immune tolerance

Citations of this article
Mendeley users who have this article in their library.


Antigen-presenting cells (APCs) can induce T cell activation as well as T cell tolerance. The molecular mechanisms by which APCs regulate this critical decision of the immune system are not well understood. Here we show that Stat3 signaling plays a critical role in the induction of antigen-specific T cell tolerance. Targeted disruption of Stat3 signaling in APCs resulted in priming of antigen-specific CD4 + T cells in response to an otherwise tolerogenic stimulus in vivo. Furthermore, APCs devoid of Stat3 effectively break antigen-specific T cell anergy in vitro. Conversely, increased Stat3 activity in APCs led to impaired antigen-specific T cell responses. Stat3 signaling provides, therefore, a novel molecular target for manipulation of immune activation/tolerance, a central decision with profound implications in autoimmunity, transplantation, and cancer immunotherapy.




Cheng, F., Wang, H. W., Cuenca, A., Huang, M., Ghansah, T., Brayer, J., … Sotomayor, E. M. (2003). A critical role for Stat3 signaling in immune tolerance. Immunity, 19(3), 425–436. https://doi.org/10.1016/S1074-7613(03)00232-2

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free