Infuência do processo de secagem e condição de armazenamento de extratos secos de bauhinia forfcata e passifora alata sobre seu perfl de dissolução

Abstract

In Brazil, most of the herbal medicinal products are considered as medicine. Therefore, it is necessary the establishment of tests to guarantee the maintenance of quality requirements during their processing and storage. The dissolution test is used to estimate the bioavailability of drugs and is routinely used in the development and the quality control of allopathic medicines. The determination of the dissolution profle of herbal products can also be an important criterion for assessing the batch-to-batch quality as well as for studies of product development and stability. This work aimed to investigate the dissolution profles of dried extracts of two medicinal plants widely used in Brazil, the Bauhinia forfcata and Passifora alata, by assessing the effect of the drying methods and storage condition on the release of the total favonoid contents. Spouted bed and spray drying were the processes used for the production of the dried extracts. The products were subjected to accelerated storage conditions (temperature of 40 ± 2ºC and relative humidity of 75 ± 5%, for 90 days). The dissolution profles of the dried extracts, before and after storage, were determined. The concentration of total favonoids was quantifed by spectrophotometry. Adequate dissolution profles of favonoids from B. forfcata and P. alata were obtained for all the dried extracts produced. The dried extracts of Passifora alata showed the complete dissolution of favonoids in the dissolution media investigated, respectively 92% and 98% of favonoids present in the dried extracts in spouted bed and spray drying after 60 minutes of the dissolution testing.