Congo red and other supramolecular structures may intercalate various foreign compounds, particularly planar ones. Such hybrid ligands, acting as a unit, may attach themselves to proteins and penetrate into their interior, together with any intercalated substances. If the intercalant is a metal complexone, a stable metalloprotein may be formed. This chapter discusses intercalation of metal complexones with metal ions bound by supramolecular Congo red as a means of introducing contrast to amyloid-like aggregates in order to trace the initial stages of amyloidogenesis. We investigate the applicability of Titan yellow carrying silver ions, and the alizarin complexone carrying tungsten and lead ions.
CITATION STYLE
Woźnicka, O., Rybarska, J., Jagusiak, A., Konieczny, L., Stopa, B., & Roterman, I. (2017). Metal ions introduced to proteins by supramolecular ligands. In Self-Assembled Molecules - New Kind of Protein Ligands: Supramolecular Ligands (pp. 61–76). Springer International Publishing. https://doi.org/10.1007/978-3-319-65639-7_4
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