Do US thyroid cancer incidence rates increase with socioeconomic status among people with health insurance? An observational study using SEER population-based data

Abstract

Objectives: The US thyroid cancer incidence rates are rising while mortality remains stable. Trends are driven by papillary thyroid cancer (PTC), the predominant cancer subtype which has a very good prognosis. We hypothesised that health insurance and high census tract socioeconomic status (SES) are associated with PTC risk. Design: Relationships between thyroid cancer incidence, insurance and census tract SES during 2007.2010 were examined in population-based cancer registries. Cases were stratified by tumour histology, size and demography. Setting: Surveillance, Epidemiology, and End Results (SEER) registries covering 30% of the US population. Results: PTCs accounted for 88% of incident thyroid cancer cases. Small PTCs (≤2 cm) accounted for 60% of cases. Unlike non-PTC cases, the majority of those diagnosed with PTC were <50 years of age and had ≤2 cm tumours. Rate ratios (RR) of PTC diagnoses increased monotonically with SES among fully insured cases. The effect was strongest for small PTCs, high- SES versus low-SES quintile RR=2.7, 95% CI 2.6 to 2.9, two-sided trend test p<0.0001. For small PTC cases with insurance, the monotonic increase in incidence rates with rising SES persisted among cases younger than 50 years of age (RR=3.3, 95% CI 3.0 to 3.5), women (RR=2.6, 95% CI 2.5 to 2.8) and Caucasians (RR=2.5, 95% CI 2.4 to 2.7). Among the less than fully insured, rates generally decreased with increasing SES. Conclusions: The >2.5-fold increase in risk of PTC diagnosis among insured individuals associated with high SES may be informative with respect to the contemporary issue of PTC overdiagnosis.