Design and Evaluation of Floating Microspheres of Pantoprazole Sodium

Abstract

In the present study, an attempt was made to prepare floating microspheres of Pantoprazole sodium by a non-aqueous solvent evaporation method. The half-life of Pantoprazole sodium is 1-1.5 hours and rapidly eliminated from the body. It is in a perfect world suited to be conveyed through floating multiunit measurements structure. Biocompatible polymers, Eudragit S100 and HPMC K 100M were utilized alongside the medication as a part of diverse extents. The prepared six formulations (F1-F6) were characterized for their drug polymer compatibility (IR study), micromeritic properties, particle size, percentage yield, scanning electron microscopy, buoyancy studies, drug encapsulation efficiency and in vitro drug release studies. The formulated microspheres were free flowing. The optical microscopic studies revealed that the particles were of the size range of 193.29-517.16 μm. SEM studies indicated that the microspheres were porous and almost spherical in shape. The prepared floating microspheres were found to produce the percentage yield of 84.43-91.93%, drug encapsulation efficiency was 65.83-90.03% and buoyancy percentage was 61.7-78.46%. In-vitro drug release studies showed cumulative percentage drug release between 69.27-79.06%. The information acquired in this study recommends that a micro particulate floating dose type of Pantoprazole sodium can be effectively intended to give delayed arrival of medication and thus enhanced bioavailability.