Chickenpox monoarthritis: Demonstration of varicella-zoster virus in joint fluid by polymerase chain reaction

Abstract

A case of chickenpox monoarthritis is described. The presence of varicella-zoster virus (VZV) within the joint was demonstrated by the detection of viral DNA in synovial fluid at a time when peripheral blood cells were negative. This strongly suggests a direct role of VZV in causing monoarthritis complicating chickenpox. The use of the polymerase chain reaction allows more rapid (2 days) confirmation of the diagnosis. Early enough diagnosis would raise the question of using acyclovir to shorten the duration of arthritis.