Background: Transcriptional networks in mouse trophoblast stem cells differentiation are not fully characterized. Results: Changes in Sox21 gene expression modulate lineage-specific markers during trophoblast stem cell differentiation. Conclusion: The expression levels of Sox21 need to be tightly regulated to achieve the right balance of terminally differentiated trophoblast cells. Significance: This is the first study showing expression and function of Sox21 in mouse placenta and trophoblast stem cells.
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Zita, M. M., Soncin, F., Natale, D., Pizzo, D., & Parast, M. (2015). Gene expression profiling reveals a novel regulatory role for Sox21 protein in mouse trophoblast stem cell differentiation. Journal of Biological Chemistry, 290(50), 30152–30162. https://doi.org/10.1074/jbc.M115.659094