The comparison of topiramate and placebo in the treatment of posttraumatic stress disorder; randomized double blind study

Abstract

Background: Posttraumatic stress disorder (PTSD) is a chronic illness and a difficult-to-treat condition. The Hypothesis that exposure to Traumatic events may sensitize or kindle limbic nuclei has led to efforts to treat PTSD with anticonvulsants. Based on the kindling hypothesis of PTSD, this clinical trial was designed to assess the clinical response to topiramate (a new anticonvulsant) as a potential Treatment for PTSD.