Mouse Brain Development

Abstract

With the enormous development of human and mouse genomics and the availability of a variety of transgenic techniques, the mouse has become the most widely used animal for basic studies of brain development and as a model for human developmental disorders. The topics are addressed using a diversity of techniques, from genetic, biochemical and cell biological to morphological and functional. The conceptual approaches also provide a framework for studies of other problems and point the way towards future research. Introduction -- Mapping Genes that Modulate Mouse Brain Development -- Genetic Interactions During Hindbrain Segmentation in the Mouse Embryo -- Neurogenetic Compartments of the Mouse Diencephalon and Some Characteristic Gene Expression Patterns -- Neuronogenesis and the Early Events of Neocortical Histogenesis -- Programmed Cell Death in Mouse Brain Development -- Neurotrophic Factors: Versatile Signals for Cell-Cell Communication in the Nervous System -- Growth Factors' Influences on the Production and Migration of Cortical Neurons -- Signalling From Tyrosine Kinases in the Developing Neurons and Glia of the Mammalian Brain -- The Role of the p35/cdk5 Kinase in Cortical Development -- The Reelin Signalling Pathway and Mouse Brain Development -- The Subpial Granular Layer in the Developing Cerebral Cortex of Rodents -- Development of Thalamocortical Projections in Normal and Mutant Mice.