Radiation-induced survival responses promote immunogenic modulation to enhance immunotherapy in combinatorial regimens

Abstract

Tumor cells that survive radiation are more sensitive to T-cell-mediated lysis due to a spectrum of biological adaptations to cellular stress (defined as immunogenic modulation), including enhanced antigen processing and cellsurface presence of calreticulin. This mechanism can be exploited to maximize clinical benefit in patients receiving radiotherapy plus immunotherapy. © 2014 Landes Bioscience.