Antimicrobial activities of monoesters of succinic acid

Abstract

Present study describes the antimicrobial activities of the di- and tri-substituted benzyl monoesters (1-27) derived from succinic anhydride. The monoesters were screened against two fungi (C. albicans and A. niger) and two bacteria (E. coli, P. mirabilis) strains. All the compounds displayed bioactivity against screened microbes. However, the activities were dependent on the nature of the substituents. Zones of inhibition and minimum inhibitory concentrations (MICs) of the monoesters are reported. Chloramphenicol and ketoconazole were used as standard antibacterial and antifungal drugs respectively. Succinic anhydride Benzyl alcohols Monoesters of succinic acid.