Synthesis, morphological, optical properties of functionalized La0.33Ca0.67MnO3 for antibacterial therapy

Abstract

A functionalized paramagnetic manganite La0.33Ca0.67MnO3 was investigated for its morphological, optical and antimicrobial properties. The manganite was capped by using a citrate ligand. The UV-visible spectrophotometer was used in monitoring the optical bands of the metal-citrate complex. It was observed to absorb in the visible region. The metal-citrate was reacted with a biologically active ligand (N-(3-nitrophenyl)-3-phenyl-2-(phenylsulfonamido) propanamide). The optical bands observed from the metal-citrate were used in monitoring the reaction between the metal-citrate and N-(3-nitrophenyl)-3-phenyl-2-(phenylsulfonamido) propanamide). The morphological property of the product formed was determined using SEMEDAX. The effect of the complex formed on the organic ligand, N-(3-nitrophenyl)-3-phenyl-2-(phenylsulfonamido) propanamide) was determined using 1H and 13C NMR. The bacterial inhibitory property of the metal-citrate-N-(3-nitrophenyl)-3-phenyl-2-(phenylsulfonamido) propanamide) complex was determined against Pseudomonas aeruginosa and Staphylococcus auerus. It was observed to inhibit the growth of Staphylococcus aureus only. The biological activities of the metal-citrate N-(3-nitrophenyl)-3-phenyl-2-(phenylsulfonamido) propanamide) suggest its use as an alternative antibacterial therapy.