Analysis of antioxidant activities contained in the Boesenbergia pandurata Schult. rhizome

Abstract

The rhizome of Boesenbergia pandurata Schult. was found to possess potent antioxidant activity in a rat brain homogenate model. Bioassay-guided isolation of the active compounds from a CH2Cl2-MeOH (1:1) extract led to the isolation of 5-hydroxy-7-methoxyflavanone, panduratin A, 5,7-dihydroxyflavanone, 2′,6′-dihydroxy-4′-methoxychalcone, 2′,4′-dihydroxy-6′-methoxychalcone, and 4-hydroxypanduratin A. Panduratin A, 4-hydroxypanduratin A, and 2′,6′-dihydroxy-4′- methoxychalcone were also found to exert neuroprotective effects.