Three new natural products, corallocins A-C (1-3), along with two known compounds were isolated from the mushroom Hericium coralloides. Their benzofuranone and isoindolinone structures were elucidated by spectral methods. All corallocins induced nerve growth factor and/or brain-derived neurotrophic factor expression in human 1321N1 astrocytes. Furthermore, corallocin B showed antiproliferative activity against HUVEC and human cancer cell lines MCF-7 and KB-3-1.
CITATION STYLE
Wittstein, K., Rascher, M., Rupcic, Z., Löwen, E., Winter, B., Köster, R. W., & Stadler, M. (2016). Corallocins A-C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides. Journal of Natural Products, 79(9), 2264–2269. https://doi.org/10.1021/acs.jnatprod.6b00371
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