Cutting Edge: The Transcription Factor Bob1 Counteracts B Cell Activation and Regulates miR-146a in B Cells

  • Lindner J
  • Kayo H
  • Hedlund S
  • et al.
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Abstract

Mice lacking the lymphocyte-specific transcription factor Bob1 (also called OBF-1 or OCA-B) fail to generate germinal centers and a robust Ig response. We show that peripheral B cells in Bob1−/− mice bear characteristics of chronically activated or anergic-like B cells and identify the immunosuppressive microRNA-146a, together with other microRNAs, as novel transcriptional targets of Bob1. The inability to restrict B cell signaling could contribute to the immunodeficient phenotype of these mice and is consistent with an important role for Bob1 in suppressing B cell activation in vivo.

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Lindner, J. M., Kayo, H., Hedlund, S., Fukuda, Y., Fukao, T., & Nielsen, P. J. (2014). Cutting Edge: The Transcription Factor Bob1 Counteracts B Cell Activation and Regulates miR-146a in B Cells. The Journal of Immunology, 192(10), 4483–4486. https://doi.org/10.4049/jimmunol.1303022

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