Chemoradiotherapy for cancer of the esophagus: Contribution of the leucovorin, 5-fluorouracil bolus, and infusion-cisplatin-radiotherapy schedule starting with two neoadjuvant chemotherapy cycles: Results from a pilot study

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Abstract

To assess feasibility and tolerance of a modification in the usual radiochemotherapy regimen for esophageal cancer by using a leucovorin, 5-fluorouracil bolus, and infusion-cisplatin regimen (six cycles), beginning with two cycles of chemotherapy before conventional radiotherapy (50 Gy), 33 patients, 30 were men, 62.8 ± 9.5 years, were treated for an esophageal carcinoma (29 squamous cell), 27 of these were in stage III (based on computed tomography scan). Neoadjuvant chemotherapy was well tolerated; concomitant radiochemotherapy was associated with severe adverse events mostly hematological in 23 patients. Complete response was achieved in 70%; median overall survival was 14 months, and 2-year survival was 40 ± 11%. More than one-third of cycles could be performed as outpatients. This regimen seems safe and efficient, and could be conducted in an outpatient basis. © 2009 Copyright the Authors Journal compilation © 2010, Wiley Periodicals, Inc.

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Vuong, T. N. T., Prisé, E. L., Vauléon, E., Boucher, E., Audrain, O., & Raoul, J. L. (2010). Chemoradiotherapy for cancer of the esophagus: Contribution of the leucovorin, 5-fluorouracil bolus, and infusion-cisplatin-radiotherapy schedule starting with two neoadjuvant chemotherapy cycles: Results from a pilot study. Diseases of the Esophagus, 23(4), 324–328. https://doi.org/10.1111/j.1442-2050.2009.01016.x

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