Physiological roles of GPR10 and PrRP signaling

19Citations
Citations of this article
35Readers
Mendeley users who have this article in their library.

Abstract

Prolactin-releasing peptide (PrRP) was first isolated from bovine hypothalamus, and was found to act as an endogenous ligand at the G-protein-coupled receptor 10 (GPR10 or hGR3). Although originally named as it can affect the secretion of prolactin from anterior pituitary cells, the potential functions for this peptide have been greatly expanded over the past decade. Anatomical, pharmacological, and physiological studies indicate that PrRP, signaling via the GPR10 receptor, may have a wide range of roles in neuroendocrinology; such as in energy homeostasis, stress responses, cardiovascular regulation, and circadian function. This review will provide the current knowledge of the PrRP and GPR10 signaling system, its putative functions, implications for therapy, and future perspectives. © 2013 Dodd and Luckman.

Cite

CITATION STYLE

APA

Dodd, G. T., & Luckman, S. M. (2013). Physiological roles of GPR10 and PrRP signaling. Frontiers in Endocrinology. https://doi.org/10.3389/fendo.2013.00020

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free