Collapsing Glomerulopathy in a Child with Galloway-Mowat Syndrome

  • Zeybek C
  • Basbozkurt G
  • Hamcan S
  • et al.
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Abstract

Galloway-Mowat syndrome (GMS) is an autosomal recessive disorder with a poor prognosis that was first defined as a triad of central nervous system involvement, hiatal hernia, and nephrotic syndrome. However, this syndrome is now known to have a heterogeneous clinical presentation. The nephrotic syndrome is steroid resistant and is responsible for the outcome. The combination of collapsing glomerulopathy and GMS is very rare. A 26-month-old boy presented with steroid-resistant nephrotic syndrome associated with neurologic findings, including microcephaly, psychomotor retardation, and nystagmus. Magnetic resonance imaging showed marked cerebral atrophy, optic atrophy, and hypomyelination. A renal biopsy was consistent with collapsing glomerulopathy. If collapsing glomerulopathy is associated with neurological abnormalities, especially with microcephaly, clinicians should consider GMS as a possible underlying cause.

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Zeybek, C., Basbozkurt, G., Hamcan, S., Ozcan, A., Gul, D., & Gok, F. (2016). Collapsing Glomerulopathy in a Child with Galloway-Mowat Syndrome. Case Reports in Nephrology, 2016, 1–5. https://doi.org/10.1155/2016/4386291

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