Synthesis, characterization, and thermal and antimicrobial activities of some novel organotin(IV): Purine base complexes

Abstract

A new series of organotin(IV) complexes with purine bases theophylline (HL1) and theobromine (L2) of the types R 3Sn(L1), R2Sn(L1)Cl, R 3Sn(L2)Cl, and R2Sn(L2)Cl 2(R = C6H5CH2-; p-ClC 6H4CH2-) have been synthesized in anhydrous THF. The complexes were characterized by elemental analysis, conductance measurements, molecular weight determinations, UV-vis, IR, 1H, 13C NMR, and mass spectral studies. Various kinetic and thermodynamic parameters of these complexes have also been determined using TG/DTA technique. The thermal decomposition techniques indicate the formation of SnO2 as a residue. The results show that the ligands act as bidentate, forming a five-member chelate ring. All the complexes are 1: 1 metal-ligand complexes. In order to assess their antimicrobial activity, the ligands and their corresponding complexes have also been tested in vitro against bacteria (E. coli, S. aureus, and P. pyocyanea) and fungi (Rhizopus oryzae and Aspergillus flavus). All the complexes exhibit remarkable activity, and the results provide evidence that the studied complexes might indeed be a potential source of antimicrobial agents. © 2013 Reena Jain et al.