Characterization of a small Porcine DNA virus

Abstract

Characteristics of a small DNA virus isolated from kidney cell cultures of healthy 3 week-old pigs are described. The virus isolate multiplies in kidney cell cultures of pig origin, produces intranuclear inclusion bodies, and hemagglutinates guinea pig, human group 0, chicken, cat, rat and mouse red blood cells. It multiplies in pigs resulting in antibody production, but is not pathogenic for newborn hamsters and mice. The virus particle is 20-22 mμ in size, hexagonal in shape and without a lipid containing envelope. Buoyant density is between 1.37 and 1.38g/ml. This virus is stable within a wide range of pH, resistant to heat (56°C), against treatment with trypsin, and lipid solvents. The porcine virus was proposed as a member of the picodna virus group, and named "Porcine Picodna Virus (PPV)". © 1968 Springer-Verlag.