Nonhormonal Medical Treatment of Male Infertility

Abstract

A nonhormonal medical treatment can be used in patients with male infertility. When the cause has not been identified, the treatment is defined empirical and the empirical nonhormonal medical treatment involves the use of anti-inflammatory, fibrinolytic and antioxidant compounds, oligo-elements, and vitamin supplementation. This empirical therapy is prescribed to patients with idiopathic or noncurable oligo-astheno-teratozoospermia and for selected normozoospermic infertile patients. The treatment is defined rational if the pathogenic mechanism can be solved or the cause be ameliorated through the use of specific treatment. This includes antibiotics, anti-inflammatory drugs, and/or antioxidants required for infection, inflammation, and/or increased oxidative stress. Combined therapies can contribute to the improvement of sperm quality.