Development of the Commercial Manufacturing Process for Nirmatrelvir in 17 Months

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Abstract

The advancement of nirmatrelvir, the active ingredient in Paxlovid, from discovery to emergency use authorization was achieved in just 17 months, requiring an unprecedented rate of chemical process development.

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Allais, C., Connor, C. G., Do, N. M., Kulkarni, S., Lee, J. W., Lee, T., … Weekly, R. M. (2023). Development of the Commercial Manufacturing Process for Nirmatrelvir in 17 Months. ACS Central Science, 9(5), 849–857. https://doi.org/10.1021/acscentsci.3c00145

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