Impedance spectroscopy as a method for the measurement of calibrated glucose solutions with concentration occurring in human blood

Abstract

This report presents the variation of impedance values in glucose-sodium chloride (0.9 %) and glucose-bovine plasma solutions at different concentrations, ranging from 50 to 400 mg/dl, with use of sensor model based on a tetrapolar current method. It is worth noticing, that changes of glucose concentration in all frequency range (5 kHz-2 MHz) are directly affected on the impedance modulus of each sample. Also, it is found that in reported method, even the smallest changes in impedance variations were clearly measurable. These findings may be the basis for possible development of a new approach, based on impedance technology, for the noninvasive monitoring of glycaemia.