Treatment of acute Chlamydia pneumoniae infection with telithromycin in C57BL/6J mice

8Citations
Citations of this article
5Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Objectives: The efficacy of telithromycin, a new ketolide antibiotic, was investigated in the treatment of acute Chlamydia pneumoniae infection in a mouse model. Methods: C57BL/6J mice were inoculated intranasally, and the effects of three different doses of telithromycin (25, 50 and 100 mg/kg) were assessed after 5 and 10 days of treatment. Lungs for culture, PCR, histopathology, and blood for serum samples were collected immediately after each treatment period and at 3 weeks post-inoculation. C. pneumoniae-specific antibodies were analysed, and the effect of treatment was assessed by culture, detection of C. pneumoniae DNA and determination of histopathological inflammatory changes in mouse lungs. Results: Culture negativity in the lungs was achieved with the higher doses, 50 and 100 mg/kg, after 10 days of treatment. C. pneumoniae DNA was not totally eradicated with the treatments, but the groups treated with 50 and 100 mg/kg doses for 10 days had the lowest DNA positivity rates (10%) 3 weeks after the inoculation. In lung histopathology, the efficacy of telithromycin on inflammatory changes was also dose-dependent: higher doses were more effective in reducing the inflammatory reaction. Overall, the 25 mg/kg dose had a weaker effect compared with the others. Conclusions: Telithromycin had both time- and dose-dependent effects on the eradication of chlamydia and on reducing infection-induced inflammatory changes in mouse lungs. © The British Society for Antimicrobial Chemotherapy 2004; all rights reserved.

Author supplied keywords

References Powered by Scopus

Chronic infections and coronary heart disease: Is there a link?

1168Citations
N/AReaders
Get full text

Association of Chlamydia pneumoniae (Strain TWAR) Infection With Wheezing, Asthmatic Bronchitis, and Adult-Onset Asthma

479Citations
N/AReaders
Get full text

Ketolides - Telithromycin, an example of a new class of antibacterial agents

130Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Immunomodulatory effects of antimicrobials in the therapy of respiratory tract infections

94Citations
N/AReaders
Get full text

Design and synthesis of 2-arylbenzimidazoles and evaluation of their inhibitory effect against Chlamydia pneumoniae

44Citations
N/AReaders
Get full text

Chlamydia pneumoniae infections in mouse models: Relevance for atherosclerosis research

44Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Törmäkangas, L., Saario, E., David, D. B., Bryskier, A., Leinonen, M., & Saikku, P. (2004). Treatment of acute Chlamydia pneumoniae infection with telithromycin in C57BL/6J mice. Journal of Antimicrobial Chemotherapy, 53(6), 1101–1104. https://doi.org/10.1093/jac/dkh213

Readers' Seniority

Tooltip

Professor / Associate Prof. 1

25%

Lecturer / Post doc 1

25%

PhD / Post grad / Masters / Doc 1

25%

Researcher 1

25%

Readers' Discipline

Tooltip

Medicine and Dentistry 3

75%

Veterinary Science and Veterinary Medic... 1

25%

Save time finding and organizing research with Mendeley

Sign up for free