We investigate a control method for disease dynamics, such as HIV and malaria, to boost the immune response using a model-based approach. In particular we apply the control method to select the appropriate immune response between Th1 and Th2 responses. The idea of state jump is introduced and discussed based on hybrid control systems. To implement the control idea we propose physically available methods for each biological system. The studies on malaria model and HIV model are supported by experimental data.
CITATION STYLE
Chang, H. J., & Astolfi, A. (2015). Immune response enhancement strategy via hybrid control perspective. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 7699, pp. 1–26). Springer Verlag. https://doi.org/10.1007/978-3-319-27656-4_1
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