Prevalence and Risk Factors of Sarcopenia in Patients With Diabetes: A Meta-analysis

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Abstract

Context: The prevalence of sarcopenia in patients with diabetes is 3 times higher than that in patients without diabetes and is associated with a poor prognosis. Objective: To investigate the global pooled prevalence and risk factors of sarcopenia in patients with diabetes. Data Sources: Relevant studies published until November 30, 2020, were identified from the PubMed, Embase, Web of Science, WanFang, CNKI, VIP, and CBM databases. Study Selection: Participants with age ≥ 18 years with clinically diagnosed diabetes. Sex and diabetes type were not restricted. Data Extraction: The data were extracted by 2 reviewers independently using a standard data collection form. Data Synthesis: The pooled prevalence of sarcopenia in patients with diabetes was 18% (95% CI, 16-20); subgroup analysis showed that sarcopenia was more prevalent in males than in females, as well as being more prevalent in Asia than in South America and Oceania. Age (odds ratio [OR], 1.10), glycated hemoglobin (HbA1c) (OR = 1.16), visceral fat area (VFA) (OR = 1.03), diabetic nephropathy (OR = 2.54), duration of diabetes (OR = 1.06), and high-sensitivity C-reactive protein (hs-CRP) (OR = 1.33) were risk factors for sarcopenia in patients with diabetes. Conclusions: Sarcopenia was more prevalent in patients with diabetes. Age, HbA1c, VFA, diabetic nephropathy, duration of diabetes, and hs-CRP were the probable risk factors. In the future, medical staff should not only pay attention to the early screening of sarcopenia in high-risk groups, but also provide information on its prevention.

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APA

Feng, L., Gao, Q., Hu, K., Wu, M., Wang, Z., Chen, F., … Ma, B. (2022). Prevalence and Risk Factors of Sarcopenia in Patients With Diabetes: A Meta-analysis. Journal of Clinical Endocrinology and Metabolism, 107(5), 1470–1483. https://doi.org/10.1210/clinem/dgab884

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